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A third cancer-related growth condition is oncogene-induced senescence (OIS), a terminal cell-cycle arrest initiated by activated Ras-type oncogenes that functions as a tumour-suppressive barrier in pre-malignant lesions in vivo (Braig et al, 2005; Michaloglou et al, 2005; Collado and Serrano, 2010; Reimann et al, 2010).

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Get dating advice and anecdotes from our very own Match bloggers on all things relationships!Because the gold-standard senescence assay, detection of the senescence-associated β-galactosidase (SA-β-gal) activity (Dimri et al, 1995), cannot be applied to formalin-fixed and paraffin-embedded (FFPE) clinical routine samples, we developed a senescence index (SI) based on FFPE-suitable immunohistochemical surrogate markers.We report here the first-time use of this SI in untreated human tumour specimens at diagnosis as a predictor for outcome to cancer therapy.Christian Connection makes it easy to break the ice.If you see someone you like, simply "wave" at them.Therapy-induced senescence (TIS) contributes to treatment outcome in pre-clinical models (Schmitt et al, 2002), and is detectable in patient cancer biopsies after neoadjuvant chemotherapy (te Poele et al, 2002; Roberson et al, 2005), but its long-term effect on clinical courses remains undetermined.

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